22" will be ok for ride quality depending on the tires you get, where you drive, etc. You will have less rubber to soak up potholes so for example I wouldn't recommend them in the NE or around Chicago. Lower profile tires will increase the ride loss. My 20" still are fine for ride quality. You can fit basically up to 34" before you need to lift. 33 1/2" if you have a wide tread. As you eat this up with wheel, you loose off road ability, towing rating, and ride quality. You pick-up handling to a point, which then decreases. This was the original reason for large wheels to begin with. Ride quality will really start to suffer with less than 5.5" in sidewall and continue to decrease expodentially as you increase rim size.
Sidewall width
Stock 17" is 8"
Stock 18" is 7.3"
My 305-55-20 is 6.7"
The popular 305-50-20 is 6.1"
305-45-22 is 5.5"
305-35-24 is 4.25"
305-30-26 is 3.5"
You get the idea. Additionally as Andy pointed out, the larger you get, the slower your acceleration will be, worse your mileage will be, bigger bumps will feel, weaker your rims will be, and expenses go up rapidly. Most guys that do some off-road on trails that don't require major mods like 8"+. The reason street driviing is better with less sidewall is the lean of the sidewall diminishes in a turn. If you get below a certain ratio of tread width to sidewaill height, for us 22", you no longer have any lean but now there isn't enough give in the tire to absorb road imperfections. The tire then bounces to compensate and you loose traction. The effect is worse handling, not better. Too many rice rocket guys don't get this.
If you want 22", don't plan on anything offroad past a well groomed dirt road, and don't live in an area with many potholes, want the best handling you can get, and don't mind sacrificing some ride quality, go for it!
Hope this helps.